免疫原
Synthesized peptide derived from human TFB2M AA range: 192-242
特异性
This antibody detects endogenous levels of TFB2M at Human/Mouse/Rat
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
功能
function:S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.,induction:By the nuclear respiratory factors NRF1 and NRF2/GABPB2 and PGC-1 coactivators.,similarity:Belongs to the rRNA adenine N(6)-methyltransferase family. KsgA subfamily.,subunit:Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.,tissue specificity:Ubiquitously expressed.,
基因名称(Gene Name)
TFB2M NS5ATP5
其他名称
h mtTFB;h mtTFB2;Hkp1;hTFB2M;mtTFB2;NS5ATP5;TFB2M;TFB2M NS5ATP5
组织表达
Ubiquitously expressed.