免疫原
Synthesized peptide derived from human S100A7 AA range: 1-51
特异性
This antibody detects endogenous levels of human S100A7
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
背景（Background）
S100 calcium binding protein A7(S100A7) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein is overexpressed in hyperproliferative skin diseases, exhibits antimicrobial activities against bacteria and induces immunomodulatory activities. [provided by RefSeq, Nov 2014],
功能
mass spectrometry: PubMed:8526920,similarity:Belongs to the S-101 family.,similarity:Contains 2 EF-hand domains.,subcellular location:Secreted by a non-classical secretory pathway.,subunit:Interacts with RANBP9.,tissue specificity:Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.,
基因名称（Gene Name）
S100A7 PSOR1 S100A7C
其他名称
Protein S100 A7;PSOR1;Psoriasin;S100A7;S100A7/Psoriasin;S100A7c;S100A7 PSOR1 S100A7C;Protein S100-A7 (Psoriasin;S100 calcium-binding protein A7)
Fields
>>IL-17 signaling pathway
细胞定位
Cytoplasm . Secreted . Secreted by a non-classical secretory pathway.
组织表达
Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.
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