免疫原
Synthesized peptide derived from human ROS (Phospho Tyr2114)
特异性
This antibody detects endogenous levels of Human,Mouse,Rat ROS (Phospho Tyr2114)
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:1000-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008],
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A chromosomal aberration involving ROS1 is found in glioblastoma multiform (GBM). An homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.,function:This is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 9 fibronectin type-III domains.,
基因名称（Gene Name）
ROS1 MCF3 ROS
蛋白名称
ROS (Phospho Tyr2114)
其他名称
c ros 1;c ros;c ros oncogene 1 receptor tyrosine kinase;c Ros receptor tyrosine kinase;c ros1;MCF 3;MCF3;Oncogene ROS;OTTHUMP17814;OTTHUMP17815;OTTHUMP4389;Proto oncogene c ros 1 protein;Proto oncogene c Ros;Proto oncogene tyrosine protein kinase ROS;Proto oncogene tyrosine protein kinase ROS precursor;Proto-oncogene c-Ros-1;Proto-oncogene tyrosine-protein kinase ROS;Receptor tyrosine kinase c ros oncogene 1;Ros 1;ROS 1C;ROS;ROS proto oncogene 1;receptor tyrosine kinase;ROS_HUMAN;ROS1;ROS1C;Transmembrane tyrosine specific protein kinase;v ros avian UR2 sarcoma virus oncogene homolog 1;v ros UR2 sarcoma virus oncogene homolog 1;ROS1 MCF3 ROS;ROS (Phospho Tyr2114);Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1;Proto-oncogene c-Ros;Receptor tyrosine kinase c-ros oncogene 1;c-Ros receptor tyrosine kinase)
细胞定位
Cell membrane ; Single-pass type I membrane protein .
组织表达
Expressed in brain. Expression is increased in primary gliomas.
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