免疫原
Synthesized peptide derived from human NUCB1 AA range: 54-104
特异性
This antibody detects endogenous levels of NUCB1 at Human/Mouse/Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010],
功能
domain:The EF-hand domains are unfolded in the absence of Ca(2+) and fold upon Ca(2+) addition.,function:Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis.,miscellaneous:Discovered as DNA-binding protein in the serum of lupus-prone mice.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the nucleobindin family.,similarity:Contains 2 EF-hand domains.,subcellular location:A small fraction of the protein may be cytoplasmic.,subunit:Interacts with GNAI2 and GNAI3.,tissue specificity:Expressed both in fetal and adult heart, lung, liver, kidney and brain, and in adult skeletal muscle, placenta and pancreas.,
基因名称（Gene Name）
NUCB1 NUC
其他名称
NUCB1;CALNUC;NUC;Nucleobindin-1;NUCB1 NUC
细胞定位
Golgi apparatus, cis-Golgi network membrane ; Peripheral membrane protein ; Lumenal side . Cytoplasm . Secreted . A small fraction of the protein may be cytoplasmic. .
组织表达
Expressed both in fetal and adult heart, lung, liver, kidney and brain, and in adult skeletal muscle, placenta and pancreas.
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