免疫原
Synthesized peptide derived from part region of human protein
特异性
S5A2 Polyclonal Antibody detects endogenous levels of protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008],
功能
catalytic activity:A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced acceptor.,disease:Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH) [MIM:264600]; also known as male pseudohermaphroditism due to 5-alpha-reductase deficiency or 5-ARD deficiency. PPSH is a rare form of male pseudohermaphroditism in which affected males develop normal internal urogenital tracts but fail to develop external male structures. Individuals with PPSH have testicles and tend to have a vagina and labia, but with a small penis capable of ejaculation instead of a clitoris (this penis, however, appears to be a clitoris at birth). These individuals are normally raised as girls. However at puberty their testes will descend, their voice will deepen and they often will develop a male sexual identity. They develop only limited facial hair and will not experience ma
蛋白名称
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (EC 1.3.1.30) (5 alpha-SR2) (SR type 2) (Steroid 5-alpha-reductase 2) (S5AR 2) (Type II 5-alpha reductase)
其他名称
5ART2;S5AR 2;ST5AR2;S5A2_HUMAN;SRD5A2;5 alpha-SR2;SR type 2;Steroid 5-alpha-reductase 2 (S5AR 2);Type II 5-alpha reductase;1.3.1.22;Q3UTZ9_MOUSE;S5A2_MOUSE;S5A2_PIG;S5A2_RAT;steroid 5 alpha-reductase 2;steroid-5-alpha-reductase;alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2);3-oxo-5-alpha-steroid 4-dehydrogenase 2;S5A2;3-oxo-5-alpha-steroid 4-dehydrogenase 2 (EC 1.3.1.30) (5 alpha-SR2) (SR type 2) (Steroid 5-alpha-reductase 2) (S5AR 2) (Type II 5-alpha reductase)
Fields
>>Steroid hormone biosynthesis;>>Metabolic pathways;>>Prostate cancer
细胞定位
Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane ; Multi-pass membrane protein .
组织表达
Expressed in high levels in the prostate and many other androgen-sensitive tissues.
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