免疫原
The antiserum was produced against synthesized peptide derived from human HSP40. AA range:271-320
特异性
HSP40 Polyclonal Antibody detects endogenous levels of HSP40 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
功能
function:Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP.,induction:By heat shock.,similarity:Contains 1 J domain.,subcellular location:Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.,subunit:Interacts with DNAJC3.,
蛋白名称
DnaJ homolog subfamily B member 1
其他名称
DnaJ (Hsp4) homolog subfmaily B member 1;DNAJ 1;DNAJ B1;DnaJ homolog subfamily B member 1;DnaJ protein homolog 1;DNAJ1;DNAJB 1;Dnajb1;DNAJB1 protein;DNJB1_HUMAN;HDJ 1;HDJ-1;HDJ1;Heat shock 4 kDa protein 1;Heat shock 4kD protein 1;Heat shock protein 4;Hsp 4;HSP4;HSPF 1;HSPF1;Human DnaJ protein 1;Radial spoke 16 homolog B;RSPH16B;Sis1;HSP40;Heat shock 40 kDa protein 1;Heat shock protein 40
Fields
>>Protein processing in endoplasmic reticulum;>>Influenza A
细胞定位
Cytoplasm . Nucleus . Nucleus, nucleolus . Translocates rapidly from the cytoplasm to the nucleus, and especially to the nucleoli, upon heat shock.
组织表达
Brain,Heart,Lung,Placenta,
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