免疫原
The antiserum was produced against synthesized peptide derived from human ATXN2L. AA range:571-620
特异性
Ataxin-2L Polyclonal Antibody detects endogenous levels of Ataxin-2L protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
功能
PTM:Arg-361 is dimethylated, probably to asymmetric dimethylarginine.,PTM:Thrombopoietin triggers the phosphorylation on tyrosine residues in a way that is dependent on MPL C-terminal domain.,sequence caution:Exon duplication.,similarity:Belongs to the ataxin-2 family.,subunit:Interacts with MPL/TPOR and EPOR and dissociates after ligand stimulation.,tissue specificity:Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells.,
蛋白名称
Ataxin-2-like protein
其他名称
A2D;A2LG;A2LP;A2RP;Ataxin 2 domain protein;Ataxin 2 like;Ataxin 2 like protein;Ataxin 2 related protein;Ataxin-2 domain protein;Ataxin-2 like;Ataxin-2-like protein;Ataxin-2-related protein;ATX2L_HUMAN;ATXN2L;ATXN2L ataxin 2 like;Ataxin-2L
Fields
>>Amyotrophic lateral sclerosis;>>Spinocerebellar ataxia;>>Pathways of neurodegeneration - multiple diseases
细胞定位
Membrane ; Peripheral membrane protein . Cytoplasm . Nucleus speckle . Cytoplasmic granule . Predominantly cytoplasmic but is also detected in nuclear speckles (PubMed:23209657). Component of cytoplasmic stress granules (PubMed:23209657). Inhibition of methylation alters nuclear localization (PubMed:25748791). Methylation does not seem to be required for localization to stress granules under stress conditions (PubMed:25748791). .
组织表达
Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells.
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
