免疫原
The antiserum was produced against synthesized Acetyl-peptide derived from human HSP90A/B around the Acetylation site of Lys292/284. AA range:251-300
特异性
Acetyl-HSP 90 (K292/284) Polyclonal Antibody detects endogenous levels of HSP 90 protein only when acetylated at K292/284.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
功能
caution:Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.,function:Molecular chaperone.,function:Molecular chaperone. Has ATPase activity.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1 and HSF1.,
基因名称（Gene Name）
HSP90AA1/HSP90AB1
蛋白名称
Heat shock protein HSP 90-alpha/Heat shock protein HSP 90-beta
其他名称
HSP 90;HSP90AA1/HSP90AB1;Heat shock protein HSP 90-alpha/Heat shock protein HSP 90-beta;HSP90AA1;HSP90A;HSPC1;HSPCA;Heat shock protein HSP 90-alpha;Heat shock 86 kDa;HSP 86;HSP86;Renal carcinoma antigen NY-REN-38;HSP90AB1;HSP90B;HSPC2;HSPCB;Heat shock protein HSP 90-beta;Heat shock 84 kDa;HSP 84;HSP84
Fields
>>Protein processing in endoplasmic reticulum;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Antigen processing and presentation;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>Th17 cell differentiation;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Salmonella infection;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Prostate cancer;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis
细胞定位
Nucleus . Cytoplasm . Melanosome . Cell membrane . Mitochondrion . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
组织表达
Adult brain,Brain,Brain cortex,Breast,Cajal-Retzius
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