免疫原
The antiserum was produced against synthesized peptide derived from human NR5A1. AA range:169-218
特异性
SF-1 Polyclonal Antibody detects endogenous levels of SF-1 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008],
功能
disease:Defects in NR5A1 are a cause of adrenocortical insufficiency without ovarian defect [MIM:184757]. The disease is characterized by severe 'slackness,' muscular hypotonia. There is decreased sodium, increased potassium and elevated ACTH.,disease:Defects in NR5A1 are a cause of XY sex reversal with or without adrenal failure [MIM:184757]. This disease is characterized by normal female external genitalia and retention of the uterus.,function:Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1/FTZF1. The SFPQ-NO
蛋白名称
Steroidogenic factor 1
其他名称
BBP;D11S636;Mammalian branch point binding protein mBBP;OTTHUMP69749;OTTHUMP6975;OTTHUMP69752;Splicing factor 1;Transcription factor ZFM1;ZFM1;Zinc finger gene in MEN1 locus;Zinc finger protein 162;ZNF162;SF1;SF-1;NR5A1;Steroidogenic factor 1;AD4BP;FTZF1;STF-1;Adrenal 4-binding protein;Fushi tarazu factor homolog 1;Nuclear receptor subfamily 5 group A member 1;Steroid hormone receptor Ad4BP
Fields
>>Cortisol synthesis and secretion;>>Cushing syndrome
组织表达
High expressed in the adrenal cortex, the ovary, the testis, and the spleen (PubMed:9177385).
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