免疫原
Synthesized pospho peptide derived from human Nuclear Receptor NR4A1 (Phospho-Ser351)
特异性
This antibody detects endogenous pospho levels of human Nuclear Receptor NR4A1 (Phospho-Ser351)
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000, ELISA(peptide)1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],
功能
function:Orphan nuclear receptor.,induction:By growth-stimulating agents.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR4 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with GADD45GIP1.,tissue specificity:Fetal muscle and adult liver, brain and thyroid.,
基因名称（Gene Name）
NR4A1 GFRP1 HMR NAK1
蛋白名称
Nuclear Receptor NR4A1 (Phospho-Ser351)
其他名称
Early response protein NAK1;GFRP 1;GFRP;GFRP1;Growth factor inducible nuclear protein N1;Growth Factor Inducible Nuclear Protein NP1;Growth Factor Response Protein 1;Hbr1;HMR;Hormone Receptor;MGC9485;N1;N1 nuclear protein;NAK 1;NAK1;Nerve growth factor IB nuclear receptor variant 1;NGFIB;NP 1;NP1;NR4A1;NR4A1_HUMAN;Nuclear hormone receptor NUR/77;Nuclear Hormone Receptor TR3;Nuclear receptor subfamily 4 group A member 1;NUR77;mouse;homolog of;Orphan nuclear receptor HMR;Orphan nuclear receptor NR4A1;Orphan nuclear receptor TR3;Orphan receptor tr3;Receptor NGFIB;ST 59;ST-59;ST59;Steroid receptor TR3;Testicular receptor 3;TR 3;TR3;TR3 orphan receptor;NR4A1 GFRP1 HMR NAK1;Nuclear Receptor NR4A1 (Phospho-Ser351);Nuclear receptor subfamily 4 group A member 1 (Early response protein NAK1;Testicular receptor 3)
Fields
>>MAPK signaling pathway;>>PI3K-Akt signaling pathway;>>Aldosterone synthesis and secretion;>>Cortisol synthesis and secretion;>>Cushing syndrome
细胞定位
Nucleus . Cytoplasm . Mitochondrion . Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340). Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950). .
组织表达
Fetal muscle and adult liver, brain and thyroid.
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