免疫原
The antiserum was produced against synthesized peptide derived from human DNAL1. AA range:121-170
特异性
Dynein LC 1 Polyclonal Antibody detects endogenous levels of Dynein LC 1 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011],
功能
similarity:Belongs to the dynein light chain LC1-type family.,similarity:Contains 4 LRR (leucine-rich) repeats.,subunit:Interacts with DNAH5.,tissue specificity:Expressed in tissues carrying motile cilia such as testis.,
蛋白名称
Dynein light chain 1 axonemal
其他名称
8 kDa dynein light chain;8kDLC;Cytoplasmic dynein light polypeptide;DLC1;DLC8;DNCL1;DNCLC1;DYL1_HUMAN;Dynein;cytoplasmic;light chain 1;Dynein light chain 1 cytoplasmic;Dynein light chain 1;Dynein light chain LC8 type 1;Dynein light chain LC8-type 1;light polypeptide 1;light chain;LC8-type 1;DYNLL1;HDLC1;LC8;LC8a;MGC126137;MGC126138;MGC72986;PIN;Protein inhibitor of neuronal nitric oxide synthase;Protein inhibitor of neuronal NOS;Dynein LC 1;DNAL1;Dynein light chain 1 axonemal;C14orf168;axonemal
Fields
>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Pathways of neurodegeneration - multiple diseases
细胞定位
Cytoplasm, cytoskeleton, cilium axoneme .
组织表达
Expressed in tissues carrying motile cilia such as respiratory epithelia, ependyma and testis.
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