免疫原
The antiserum was produced against synthesized peptide derived from human CLIP3. AA range:361-410
特异性
CLIP3 Polyclonal Antibody detects endogenous levels of CLIP3 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010],
功能
domain:Microtubule association is inhibited by the ANK repeats and the Golgi localization region (GoLD).,function:Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics.,miscellaneous:The N-terminal half is dispensable for proper Golgi targeting, whereas the GoLD region is required.,similarity:Contains 2 CAP-Gly domains.,similarity:Contains 3 ANK repeats.,subcellular location:Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae.,subunit:Homodimer.,
蛋白名称
CAP-Gly domain-containing linker protein 3
其他名称
155P14Rik;AI844915;CAP GLY domain containing linker protein 3;CAP-Gly domain-containing linker protein 3;CLIP 17 related 59 kDa protein;CLIP-17-related 59 kDa protein;clip3;CLIP3_HUMAN;CLIPR 59;CLIPR-59;CLIPR59;Cytoplasmic linker protein 17 related 59 kDa protein;Cytoplasmic linker protein 17-related 59 kDa protein;Restin like 1;RSNL1;Cytoplasmic linker protein 170-related 59 kDa protein;CLIP-170-related 59 kDa protein
细胞定位
Cell membrane ; Lipid-anchor . Cytoplasm . Golgi apparatus, Golgi stack . Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae.
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