免疫原
Synthetic Peptide of β I tubulin
特异性
The antibody detects endgenousβ I tubulin proteins.
组成（Formulation）
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
稀释比例
WB: 1:500-10000 IF 1:200 IHC 1:50-300
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.[provided by RefSeq, Jul 2010],
功能
function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,similarity:Belongs to the tubulin family.,subunit:Dimer of alpha and beta chains.,
蛋白名称
Tubulin beta-1 chain
其他名称
Tubulin β;TUBB1;Tubulin beta-1 chain;TUBB2A;TUBB2;Tubulin beta-2A chain;TUBB2B;Tubulin beta-2B chain;TUBB4B;TUBB2C;Tubulin beta-4B chain;Tubulin beta-2 chain;Tubulin beta-2C chain;TUBB3;TUBB4;Tubulin beta-3 chain;Tubulin beta-4 chain;Tubulin beta-III;TUBB4A;TUBB5;Tubulin beta-4A chain;Tubulin 5 beta;TUBB;OK/SW-cl.56;Tubulin beta chain;Tubulin beta-5 chain;TUBB6;Tubulin beta-6 chain;TUBB8;Tubulin beta-8 chain
Fields
>>Phagosome;>>Gap junction;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Pathogenic Escherichia coli infection;>>Salmonella infection
细胞定位
Cytoplasm, cytoskeleton .
组织表达
Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins.
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