免疫原
The antiserum was produced against synthesized peptide derived from human USP19. AA range:391-440
特异性
USP19 Polyclonal Antibody detects endogenous levels of USP19 protein.
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景(Background)
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 MYND-type zinc finger.,similarity:Contains 2 CS domains.,
功能
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 MYND-type zinc finger.,similarity:Contains 2 CS domains.,
蛋白名称
Ubiquitin carboxyl-terminal hydrolase 19
其他名称
EC:3.4.19.12;KIAA0891;Ubiquitin carboxyl-terminal hydrolase 19;Ubiquitin thioesterase 19;Ubiquitin-specific-processing protease 19;USP19;ZMYND9;Deubiquitinating enzyme 19;Zinc finger MYND domain-containing protein 9
细胞定位
Endoplasmic reticulum membrane ; Single-pass membrane protein .
组织表达
Brain,Epithelium,Skin,Testis,