免疫原
Synthesized peptide derived from the Internal region of human UBE2G1.
特异性
UBE2G1 Polyclonal Antibody detects endogenous levels of UBE2G1 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008],
功能
catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,function:Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of muscle-specific proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,tissue specificity:Widely expressed, mainly in skeletal muscle.,
蛋白名称
Ubiquitin-conjugating enzyme E2 G1
其他名称
Ubiquitin carrier protein G1;UBE2G;UBC7;EC:2.3.2.23;E217K;UBE2G1;Ubiquitin-conjugating enzyme E2 G1;Ubiquitin-protein ligase G1
Fields
>>Ubiquitin mediated proteolysis;>>Protein processing in endoplasmic reticulum;>>Parkinson disease;>>Pathways of neurodegeneration - multiple diseases
细胞定位
cytoplasm,extracellular exosome,
组织表达
Widely expressed, mainly in skeletal muscle.
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