免疫原
The antiserum was produced against synthesized peptide derived from human TAT. AA range:255-304
特异性
TAT Polyclonal Antibody detects endogenous levels of TAT protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008],
功能
catalytic activity:L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.,cofactor:Pyridoxal phosphate.,disease:Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:276600]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation.,pathway:Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 2/6.,similarity:Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homodimer.,
蛋白名称
Tyrosine aminotransferase
其他名称
EC:2.6.1.5;L-tyrosine:2-oxoglutarate aminotransferase;tyrosine aminotransferase;TAT
Fields
>>Ubiquinone and other terpenoid-quinone biosynthesis;>>Cysteine and methionine metabolism;>>Tyrosine metabolism;>>Phenylalanine metabolism;>>Phenylalanine, tyrosine and tryptophan biosynthesis;>>Metabolic pathways
细胞定位
mitochondrion,cytosol,
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