免疫原
The antiserum was produced against synthesized peptide derived from human LYPLA1. AA range:51-100
特异性
LYPLA1 Polyclonal Antibody detects endogenous levels of LYPLA1 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013],
功能
catalytic activity:Palmitoyl-protein + H(2)O = palmitate + protein.,function:Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Also has low lysophospholipase activity.,similarity:Belongs to the AB hydrolase 2 family.,subunit:Homodimer.,
蛋白名称
Acyl-protein thioesterase 1
其他名称
EC:3.1.2.22;EC:3.1.2.-;APT-1;APT1;APT 1;LYPLA1;Acyl-protein thioesterase 1;LPL1;hAPT1;Lysophospholipase 1;Lysophospholipase I;LPL-I;LysoPLA I
Fields
>>Glycerophospholipid metabolism;>>Choline metabolism in cancer
细胞定位
Cytoplasm . Cell membrane . Nucleus membrane . Endoplasmic reticulum . Shows predominantly a cytoplasmic localization with a weak expression in the cell membrane, nuclear membrane and endoplasmic reticulum. .
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