免疫原
Synthesized peptide derived from human
特异性
This antibody detects endogenous levels of VDAC2 at Human, Mou
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0
纯化工艺（Immunogen）
Synthesized peptide derived from human VDAC
功能
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol . Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathwa
蛋白名称
Voltage-dependent anion-selective channel protein 2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2)
细胞定位
Mitochondrion outer membrane . Membrane . May localize to non-mitochondrial membranes. .
组织表达
Expressed in erythrocytes (at protein level) (PubMed:27641616). Expressed in all tissues examined (PubMed:8420959)
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