免疫原
Synthetic Peptide of EGFR AA range: 300-400
特异性
The antibody detects endogenous EGFR proteins.
来源
Monoclonal, Mouse IgG2a, Kappa
组成（Formulation）
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and
50% Glycerol.
稀释比例
WB 1:1000,ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse ascites by affinity-
chromatography using specific immunogen.
背景（Background）
The protein encoded by this gene is a transmembrane glycoprotein that is a
member of the protein kinase superfamily. This protein is a receptor for members
of the epidermal growth factor family. EGFR is a cell surface protein that binds to
epidermal growth factor. Binding of the protein to a ligand induces receptor
dimerization and tyrosine autophosphorylation and leads to cell proliferation.
Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun
2016],
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine
phosphate.,disease:Defects in EGFR are associated with lung cancer
[MIM:211980].,function:Isoform 2/truncated isoform may act as an
antagonist.,function:Receptor for EGF, but also for other members of the EGF
family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth
factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell
growth and differentiation. Phosphorylates MUC1 in breast cancer cells and
increases the interaction of MUC1 with C-SRC and CTNNB1/beta-
catenin.,miscellaneous:Binding of EGF to the receptor leads to dimerization,
internalization of the EGF-receptor complex, induction of the tyrosine kinase
activity, stimulation of cell DNA synthesis, and cell proliferation.,online
information:EGFR entry,PTM:Monoubiquitinated and polyubiquitinated upon EGF
stimu
蛋白名称
Epidermal growth factor receptor
Fields
>>EGFR tyrosine kinase inhibitor resistance;>>Endocrine resistance;>>MAPK
signaling pathway;>>ErbB signaling pathway;>>Ras signaling pathway;>>Rap1
signaling pathway;>>Calcium signaling pathway;>>HIF-1 signaling
pathway;>>FoxO signaling pathway;>>Phospholipase D signaling
pathway;>>Endocytosis;>>PI3K-Akt signaling pathway;>>Focal
adhesion;>>Adherens junction;>>Gap junction;>>JAK-STAT signaling
pathway;>>Regulation of actin cytoskeleton;>>GnRH signaling
pathway;>>Estrogen signaling pathway;>>Oxytocin signaling pathway;>>Relaxin
signaling pathway;>>Parathyroid hormone synthesis, secretion and
action;>>Cushing syndrome;>>Epithelial cell signaling in Helicobacter pylori
infection;>>Shigellosis;>>Hepatitis C;>>Human cytomegalovirus
infection;>>Human papillomavirus infection;>>Coronavirus disease -
COVID-19;>>Pathways in cancer;>>Proteoglycans in cancer;>>MicroRNAs in
cancer;>>Chemical carcinogenesis - receptor activation;>>Chemical
carcinogenesis - reactive oxygen species;>>Colorectal cance
细胞定位
MAPK_ERK_Growth;MAPK_G_Protein;ErbB_HER;Calcium;Cytokine-cytokine
receptor interaction;Endocytosis;Dorso-ventral axis formation;Focal
adhesion;Adherens_Junction;Gap junction;Regulates Actin and Cytosk
组织表达
Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome . Endosome membrane. Nucleus . In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029). Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536,PubMed:17909029). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). .; [Isoform 2]: Secreted.
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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