免疫原
Purified recombinant fragment of human JMJD1A expressed in E. Coli.
特异性
JMJD1A Monoclonal Antibody detects endogenous levels of JMJD1A protein.
组成（Formulation）
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺（Immunogen）
Affinity purification
背景（Background）
This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],
功能
cofactor:Binds 1 Fe(2+) ion per subunit.,domain:Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.,domain:The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.,function:Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1
蛋白名称
Lysine-specific demethylase 3A
其他名称
KDM3A;JMJD1A;JmjC domain-containing histone demethylation protein 2A;JHMD2A;Lysine-specific demethylase 3A;JHDM2A;JMJD1;KIAA0742;TSGA;Jumonji domain-containing protein 1A
细胞定位
Cytoplasm . Nucleus . Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity). .
组织表达
Adrenal gland,Brain,Fetal kidney,Salivary gland,Testis,
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