免疫原
Synthetic Peptide of Histone H2B (Acetyl Lys12)
特异性
The antibody detects endogenous Histone H2B (Acetyl Lys12) protein.
组成（Formulation）
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
背景（Background）
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015],
功能
function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,PTM:Monoubiquitination of Lys-122 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II.,similarity:Belongs to the histone H2B family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
基因名称（Gene Name）
HIST1H2BC
蛋白名称
Histone H2B type 1-A/Histone H2B type 1-B/Histone H2B type 1-C/E/F/G/I
其他名称
Ac Histone H2B;Ac Histone H2B (Lys12);Ac Histone H2B Lys12;Ac Histone H2B-Lys12;Acetyl Histone;Histone H2B;HIST1H2BC;Histone H2B type 1-A/Histone H2B type 1-B/Histone H2B type 1-C/E/F/G/I;HIST1H2BA;TSH2B;Histone H2B type 1-A;testis;Testis-specific histone H2B;HIST1H2BB;H2BFF;Histone H2B type 1-B;Histone H2B.1;Histone H2B.f;H2B/f;H2BFL;HIST1H2BE;H2BFH;HIST1H2BF;H2BFG;HIST1H2BG;H2BFA;HIST1H2BI;H2BFK;Histone H2B type 1-C/E/F/G/I;Histone H2B.1 A;Histone H2B.a;H2B/a;Histone H2B.g;H2B/g;Histone H2B.h;H2B/h;Histone H2B.k;H2B/k;Histone H2B.l;H2B/l;H2BK12AC
Fields
>>Neutrophil extracellular trap formation;>>Alcoholism;>>Viral carcinogenesis;>>Systemic lupus erythematosus
人基因ID
255626/3018/3017/8339/8343/8344/8346/8347
人蛋白质序列数据库
Q96A08/P33778/P62807
小鼠基因ID
319177/319178/319179
细胞定位
Nucleus . Chromosome .
组织表达
Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level). Also found in some fat cells.
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