免疫原
Purified recombinant fragment of human M-CSF expressed in E. Coli.
特异性
M-CSF Monoclonal Antibody detects endogenous levels of M-CSF protein.
组成（Formulation）
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200
纯化工艺（Immunogen）
Affinity purification
背景（Background）
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011],
功能
function:Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.,PTM:Glycosylation and proteolytic cleavage yield different soluble forms. A high molecular weight soluble form is a proteoglycan containing chondroitin sulfate.,PTM:Isoform 1 is N- and O-glycosylated. Isoform 3 is N-glycosylated.,subunit:Homodimer or heterodimer; disulfide-linked.,
蛋白名称
Macrophage colony-stimulating factor 1
其他名称
CSF1; Macrophage colony-stimulating factor 1; CSF-1; M-CSF; MCSF; Lanimostim
Fields
>>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>PI3K-Akt signaling pathway;>>Osteoclast differentiation;>>Hematopoietic cell lineage;>>TNF signaling pathway;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Rheumatoid arthritis
细胞定位
Cell membrane ; Single-pass type I membrane protein .; [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space.
组织表达
Endometrium,Kidney,Pancreatic carcinoma,T lymphoblast,Trophoblast,Urine,
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