免疫原
Recombinant human IFN-γ (BioSource company, Cat.No. PHC4033)
特异性
IFN-γ Monoclonal Antibody detects endogenous levels of IFN-γ protein.
组成（Formulation）
Purified antibody in PBS containing 0.03% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺（Immunogen）
Affinity purification
背景（Background）
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015],
功能
disease:In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.,function:Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.,online information:Interferon ga
其他名称
IFNG; Interferon gamma; IFN-gamma; Immune interferon
Fields
>>Proteasome;>>Cytokine-cytokine receptor interaction;>>HIF-1 signaling pathway;>>Necroptosis;>>TGF-beta signaling pathway;>>Osteoclast differentiation;>>Antigen processing and presentation;>>JAK-STAT signaling pathway;>>Natural killer cell mediated cytotoxicity;>>IL-17 signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>T cell receptor signaling pathway;>>Type I diabetes mellitus;>>Leishmaniasis;>>Chagas disease;>>African trypanosomiasis;>>Malaria;>>Toxoplasmosis;>>Amoebiasis;>>Tuberculosis;>>Hepatitis C;>>Influenza A;>>Herpes simplex virus 1 infection;>>Pathways in cancer;>>PD-L1 expression and PD-1 checkpoint pathway in cancer;>>Inflammatory bowel disease;>>Systemic lupus erythematosus;>>Rheumatoid arthritis;>>Allograft rejection;>>Graft-versus-host disease;>>Fluid shear stress and atherosclerosis
组织表达
Released primarily from activated T lymphocytes.
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