免疫原
Purified recombinant fragment of human GM-CSF (aa18-144) expressed in E. Coli.
特异性
GM-CSF Monoclonal Antibody detects endogenous levels of GM-CSF protein.
组成（Formulation）
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺（Immunogen）
Affinity purification
背景（Background）
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008],
功能
function:Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.,online information:Clinical information on Leukine,pharmaceutical:Available under the names Leukine (Immunex) and Leucomax (Novartis). Used in myeloid reconstitution following bone marrow transplant, bone marrow transplant engraftment failure or delay, mobilization and following transplantation of autologous peripheral blood progenitor cells, and following induction chemotherapy in older adults with acute myelogenous leukemia.,polymorphism:Variant Ile-117 may be a risk factor for atopic asthma.,similarity:Belongs to the GM-CSF family.,subunit:Monomer.,
蛋白名称
Granulocyte-macrophage colony-stimulating factor
其他名称
CSF2; GMCSF; Granulocyte-macrophage colony-stimulating factor; GM-CSF; Colony-stimulating factor; CSF; Molgramostin; Sargramostim
Fields
>>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway;>>Hematopoietic cell lineage;>>Natural killer cell mediated cytotoxicity;>>IL-17 signaling pathway;>>T cell receptor signaling pathway;>>Fc epsilon RI signaling pathway;>>TNF signaling pathway;>>Shigellosis;>>Amoebiasis;>>Human T-cell leukemia virus 1 infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Coronavirus disease - COVID-19;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia;>>Rheumatoid arthritis
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