免疫原
Synthesized peptide derived from human PSAP
特异性
The antibody can specifically recognize human PSAP protein.
来源
Mouse, Monoclonal/IgG2b, Kappa
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.106% sodium azide.
稀释比例
IHC-p 1:100-500, WB 1:200-1000, IF 1:100-500
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008],
功能
catalytic activity:A phosphate monoester + H(2)O = an alcohol + phosphate.,similarity:Belongs to the histidine acid phosphatase family.,subcellular location:Predominantly localized in the plasma membrane but also detected in intracellular vesicles.,subunit:Homodimer.,
其他名称
Prostatic acid phosphatase (PAP;EC 3.1.3.2;5'-nucleotidase;5'-NT;EC 3.1.3.5;Ecto-5'-nucleotidase;Thiamine monophosphatase;TMPase) [Cleaved into: PAPf39]
细胞定位
[Isoform 1]: Secreted .; [Isoform 2]: Cell membrane ; Single-pass type I membrane protein . Lysosome membrane ; Single-pass type I membrane protein . Nucleus . Cytoplasm, cytosol . Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles (PubMed:17638863). Colocalizes with LAMP2 on the lysosome membrane (PubMed:17897319). .
组织表达
Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Low expression in prostate carcinoma cells and tissues. ; [Isoform 2]: Widely expressed. Expressed in the sarcolemma of skeletal muscle.
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