免疫原
Synthesized peptide derived from human CD141
特异性
The antibody can specifically recognize human CD141 protein.
来源
Mouse, Monoclonal/IgG2b, kappa
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.58% sodium azide.
稀释比例
IHC-p 1:100-500, WB 1:200-1000, IF 1:100-500
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
背景（Background）
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008],
功能
disease:Defects in THBD are the cause of thrombophilia due to thrombomodulin defect (THR-THBDD) [MIM:188040]. THR-THBDD is a hemostatic disorder characterized by a tendency to thrombosis.,function:Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.,online information:Thrombomodulin,online information:Thrombomodulin entry,PTM:N-glycosylated.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 6 EGF-like domains.,tissue specific
基因名称（Gene Name）
THBD THRM
其他名称
Thrombomodulin (TM;Fetomodulin;CD antigen CD141)
Fields
>>Complement and coagulation cascades;>>AGE-RAGE signaling pathway in diabetic complications;>>Fluid shear stress and atherosclerosis
细胞定位
Membrane; Single-pass type I membrane protein.
组织表达
Endothelial cells are unique in synthesizing thrombomodulin.
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