免疫原
Synthesized peptide derived from human Glial Fibrillary Acidic Protein
特异性
The antibody can specifically recognize human GFAP protein.
来源
Mouse, Monoclonal/IgG1, Kappa
组成（Formulation）
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008],
功能
alternative products:Isoforms differ in the C-terminal region which is encoded by alternative exons,disease:Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.,function:GFAP, a class-III intermediate filament, is a cell-spe
蛋白名称
wu:fb34h11;ALXDRD;cb345;etID36982.3;FLJ42474;FLJ45472;GFAP;GFAP_HUMAN;gfapl;Glial fibrillary acidic protein;Intermediate filament protein;wu:fk42c12;xx:af506734;zgc:110485
简称
Glial Fibrillary Acidic Protein
其他名称
wu:fb34h11;ALXDRD;cb345;etID36982.3;FLJ42474;FLJ45472;GFAP;GFAP_HUMAN;gfapl;Glial fibrillary acidic protein;Intermediate filament protein;wu:fk42c12;xx:af506734;zgc:110485
Fields
>>JAK-STAT signaling pathway
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