免疫原
Purified recombinant human CaMKIV protein fragments expressed in E.coli.
特异性
CaMKIV Monoclonal Antibody detects endogenous levels of CaMKIV protein.
组成（Formulation）
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
稀释比例
Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
纯化工艺（Immunogen）
Affinity purification
背景（Background）
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008],
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by Ca(2+)/calmodulin. Binding of calmodulin may releave intrasteric autoinhibition. Must be phosphorylated to be maximally active. Phosphorylated by CAMKK1 or CAMKK2. Autophosphorylation of the N-terminus is required for full activation. In part, activity is independent on Ca(2+)/calmodulin and autophosphorylation of Ser-336 allows to switch to a Ca(2+)/calmodulin-independent state (By similarity). Probably inactivated by serine/threonine protein phosphatase 2A.,function:Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role i
蛋白名称
Calcium/calmodulin-dependent protein kinase type IV
其他名称
CAMK4; CAMK; CAMK-GR; CAMKIV; Calcium/calmodulin-dependent protein kinase type IV; CaMK IV; CaM kinase-GR
Fields
>>Calcium signaling pathway;>>cAMP signaling pathway;>>Longevity regulating pathway;>>Apelin signaling pathway;>>Osteoclast differentiation;>>Long-term potentiation;>>Neurotrophin signaling pathway;>>Cholinergic synapse;>>Oxytocin signaling pathway;>>Aldosterone synthesis and secretion;>>Amphetamine addiction;>>Alcoholism;>>Glioma
细胞定位
Cytoplasm. Nucleus. Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). .
组织表达
Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.
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