免疫原
Synthetic peptide from human protein at AA range: 61-110
特异性
The antibody detects endogenous PDGF-C
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
platelet derived growth factor C(PDGFC) Homo sapiens The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010],
功能
developmental stage:In the fetal kidney, detected in the developing mesangium, ureteric bud epithelium and the undifferentiated mesenchyme (at protein level).,disease:Downstream target of EWSR1 fusion proteins, contributing to the Ewin family tumors (EFT) malignant phenotype.,disease:Expression increased in patients with uterine leiomyoma (UL).,disease:Predominant PDGF isoform present in patients with proliferative vitreoretinopathy (PVR). Plasmin is the major protease that processes PDGFC in the vitreous of PVR patients.,disease:The medulloblastoma phenotype is associated with PDGFR alpha expression and activation, with PDGFC as a major player in such endogenous autocrine loop.,function:Potent mitogen and chemoattractant for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three sta
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