免疫原
Synthesized peptide derived from human VR1 (Phospho-Ser502)
特异性
This antibody detects endogenous levels of VR1 (Phospho-Ser502) at Human, Mouse,Rat
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.106% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
transient receptor potential cation channel subfamily V member 1(TRPV1) Homo sapiens Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008],
功能
domain:The association domain (AD) is necessary for self-association.,enzyme regulation:Channel activity is activated via the interaction with PIRT and phosphatidylinositol-4,5-bisphosphate (PIP2). Both PIRT and PIP2 are required to activate channel activity.,function:Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.,miscellaneous:Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.,PTM:Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, proba
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