免疫原
Synthesized peptide derived from human GRP4 AA range: 487-537
特异性
This antibody detects endogenous levels of human GRP4
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
蛋白名称
RAS guanyl-releasing protein 4
Fields
>>MAPK signaling pathway;>>Ras signaling pathway;>>Pathways in cancer
细胞定位
Cytoplasm. Cell membrane. Recruited to membranes upon activation by DAG.
组织表达
Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.
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