免疫原
Synthesized peptide derived from human EST1 AA range: 7-57
特异性
This antibody detects endogenous levels of EST1 at Human/Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.142% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],
功能
catalytic activity:A carboxylic ester + H(2)O = an alcohol + a carboxylate.,enzyme regulation:Activated by CHAPS.,function:Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl CoA ester.,PTM:Contains sialic acid.,similarity:Belongs to the type-B carboxylesterase/lipase family.,subunit:Homotrimer and homohexamer. Binds to beta-glucuronidase.,tissue specificity:Expressed predominantly in liver with lower levels in heart and lung.,
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
