免疫原
Synthesized peptide derived from human protein . at AA range: 201-250
特异性
TIA1 Polyclonal Antibody detects endogenous levels of protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq, Jul 2008],
功能
function:RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.,PTM:TIA-1 major granule-associated species is a 15-kDa protein (p15-TIA-1) that seems to be derived by proteolytic processing from the C-terminus of p40-TIA-1.,similarity:Contains 3 RRM (RNA recognition motif) domains.,subcellular location:Cytoplasmic granules of cytolytic T-lymphocytes.,
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