免疫原
Synthesized peptide derived from human protein . at AA range: 360-440
特异性
SYNE2 Polyclonal Antibody detects endogenous levels of protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
IHC-p 1:50-300. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],
功能
domain:The Klarsicht domain mediates the nuclear envelope targeting.,function:Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which theters the nucleus to the cytoskeleton. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm.,similarity:Belongs to the nesprin family.,similarity:Contains 1 actin-binding domain.,similarity:Contains 1 KASH domain.,similarity:Contains 13 LRR (leucine-rich) repeats.,similarity:Contains 2 CH (calponin-homology) domains.,similarity:Contains 9 spectrin repeats.,subcellular location:The largest part of the protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. Remains associated with the nuclear envelope during its breakdown in mitotic cells.,subunit:Interacts with F-actin
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