免疫原
Synthesized peptide derived from part region of human protein
特异性
LRSM1 Polyclonal Antibody detects endogenous levels of protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jan 2012],
功能
domain:The coiled coil domains interact with the SB domain of TSG101.,domain:The PTAP motifs mediate the binding to UEV domains.,function:E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 5 LRR (leucine-rich) repeats.,subcellular location:Displays a punctuate distribution and localizes to a submembranal ring.,subunit:Interacts with TSG101.,
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