免疫原
Purified recombinant human Arrestin-β-2 (C-terminus) protein fragments expressed in E.coli.
特异性
Arrestin-β-2 Monoclonal Antibody detects endogenous levels of Arrestin-β-2 protein.
组成（Formulation）
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
稀释比例
Western Blot: 1/1000 - 1/2000. Immunofluorescence: 1/100 - 1/500. Not yet tested in other applications.
纯化工艺（Immunogen）
Affinity purification
背景（Background）
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012],
功能
function:Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.,online information:Arrestin entry,similarity:Belongs to the arrestin family.,
其他名称
ARRB2; ARB2; ARR2; Beta-arrestin-2; Arrestin beta-2
Fields
>>MAPK signaling pathway;>>Chemokine signaling pathway;>>Endocytosis;>>Hedgehog signaling pathway;>>Dopaminergic synapse;>>Olfactory transduction;>>Relaxin signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>GnRH secretion;>>Morphine addiction;>>Chemical carcinogenesis - receptor activation
细胞定位
Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs.
组织表达
Brain,Cord blood,Endometrium,Muscle,Pancreas,Testis,Thyroid,
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