免疫原
The antiserum was produced against synthesized peptide derived from human CLIP1. AA range:1291-1340
特异性
CLIP-170 Polyclonal Antibody detects endogenous levels of CLIP-170 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
功能
function:Seems to be a intermediate filament associated protein that links endocytic vesicles to microtubules.,similarity:Contains 2 CAP-Gly domains.,subcellular location:Associated with the cytoskeleton.,tissue specificity:Highly expressed in the Reed-Sternberg cells of Hodgkin's disease.,
蛋白名称
CAP-Gly domain-containing linker protein 1
其他名称
CLIP1; CYLN1; RSN; CAP-Gly domain-containing linker protein 1; Cytoplasmic linker protein 1; Cytoplasmic linker protein 170 alpha-2; CLIP-170; Reed-Sternberg intermediate filament-associated protein; Restin
Fields
>>mTOR signaling pathway
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasmic vesicle membrane ; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle . Localizes to microtubule plus ends (PubMed:21646404, PubMed:17889670). Localizes preferentially to the ends of tyrosinated microtubules (By similarity). Accumulates in plasma membrane regions with ruffling and protrusions. Associates with the membranes of intermediate macropinocytic vesicles (PubMed:12433698). .
组织表达
Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease.
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