免疫原
The antiserum was produced against synthesized peptide derived from human NOX5. AA range:677-726
特异性
Nox5 Polyclonal Antibody detects endogenous levels of Nox5 protein.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011],
功能
cofactor:FAD.,cofactor:Magnesium.,developmental stage:Expressed in fetal tissues.,enzyme regulation:Activated by calcium which induces conformational changes and interaction between the N-terminal regulatory region and the C-terminal catalytic region. Inhibited by diphenylene iodonium.,function:Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis.,induction:Down-regulated by TGFB1.,miscellaneous:Isoforms 3 and 4 of this protein have four functional calcium-binding sites. Isoforms 1 and 2 have the third EF-hand domain interrupted by an insert.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 ferric oxidoreductase domain.,similarity:Contains 4 EF-hand domains.,tissue specificity:Mainly expre
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
