免疫原
The antiserum was produced against synthesized peptide derived from human CBR1. AA range:181-230
特异性
Carbonyl Reductase 1 Polyclonal Antibody detects endogenous levels of Carbonyl Reductase 1 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013],
功能
catalytic activity:(13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH.,catalytic activity:(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.,catalytic activity:R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.,function:Catalyzes the reduction of a wide variety of carbonyl compounds including the antitumor anthracycline antibiotics. Can convert prostaglandin E2 to prostaglandin F2-alpha.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,subunit:Monomer.,
蛋白名称
Carbonyl reductase [NADPH] 1
其他名称
CBR1; CBR; CRN; Carbonyl reductase [NADPH] 1; 15-hydroxyprostaglandin dehydrogenase [NADP(+)]; NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase
Fields
>>Arachidonic acid metabolism;>>Folate biosynthesis;>>Metabolism of xenobiotics by cytochrome P450;>>Metabolic pathways;>>Chemical carcinogenesis - DNA adducts;>>Chemical carcinogenesis - reactive oxygen species
组织表达
Expressed in kidney (at protein level).
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