免疫原
Purified recombinant human CYP7A1 (C-terminus) protein fragments expressed in E.coli.
特异性
CYP7A1 Monoclonal Antibody detects endogenous levels of CYP7A1 protein.
组成（Formulation）
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
稀释比例
Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
纯化工艺（Immunogen）
Affinity purification
背景（Background）
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010],
功能
catalytic activity:Cholesterol + NADPH + O(2) = 7-alpha-hydroxycholesterol + NADP(+) + H(2)O.,cofactor:Heme group.,online information:Cholesterol-7 alpha-hydroxylase entry,pathway:Lipid metabolism; bile acid biosynthesis.,similarity:Belongs to the cytochrome P450 family.,
蛋白名称
Cholesterol 7-alpha-monooxygenase
其他名称
CYP7A1; CYP7; Cholesterol 7-alpha-monooxygenase; CYPVII; Cholesterol 7-alpha-hydroxylase; Cytochrome P450 7A1
Fields
>>Primary bile acid biosynthesis;>>Steroid hormone biosynthesis;>>Metabolic pathways;>>PPAR signaling pathway;>>Bile secretion;>>Cholesterol metabolism
细胞定位
Endoplasmic reticulum membrane ; Single-pass membrane protein . Microsome membrane ; Single-pass membrane protein .
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