hnRNP A2/B1 Polyclonal Antibody

宿主

反应性

应用

WB;IHC;IF;ELISA

分子量（DA）

36+38kD

免疫原

The antiserum was produced against synthesized peptide derived from human hnRNP A2/B1. AA range:1-50

特异性

hnRNP A2/B1 Polyclonal Antibody detects endogenous levels of hnRNP A2/B1 protein.

来源

Polyclonal, Rabbit,IgG

组成（Formulation）

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

稀释比例

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

纯化工艺（Immunogen）

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

浓度

1 mg/ml

背景（Background）

This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008],

功能

function:Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleous.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subcellular location:Component of ribonucleosomes. Predominantly nucleoplasmic, however isoform A2 is also found in the cytoplasm of cells in some tissues. Not found in the nucleolus.,subunit:Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRNPA1, HNRNPA2B1, HNRPA3, HNRNPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRNPR, HNRNPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA

基因名称（Gene Name）

HNRNPA2B1

蛋白名称

Heterogeneous nuclear ribonucleoproteins A2/B1

简称

hnRNP A2/B1

其他名称

HNRNPA2B1; HNRPA2B1; Heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1

Fields

>>Amyotrophic lateral sclerosis

人基因ID

3181

人蛋白质序列数据库

P22626

小鼠基因ID

100000000

小鼠蛋白质序列数据库

O88569

大鼠基因ID

大鼠蛋白质序列数据库

细胞定位

Nucleus . Nucleus, nucleoplasm . Cytoplasm . Cytoplasmic granule . Secreted, extracellular exosome . Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). Component of ribonucleosomes (PubMed:17289661). Not found in the nucleolus (PubMed:17289661). Found in exosomes following sumoylation (PubMed:24356509). .; [Isoform A2]: Nucleus . Cytoplasm . Predominantly nucleoplasmic, however is also found in the cytoplasm of cells in some tissues (PubMed:17289661). .

组织表达

Brain,Cajal-Retzius cell,Cervix carcinoma,Epitheliu

储存（Storage）

-20°C/1 year

BYab-01799

产品简介>

宿主

反应性

应用

分子量（DA）

免疫原

特异性

来源

组成（Formulation）

稀释比例

纯化工艺（Immunogen）

浓度

背景（Background）

功能

基因名称（Gene Name）

蛋白名称

简称

其他名称

Fields

人基因ID

人蛋白质序列数据库

小鼠基因ID

小鼠蛋白质序列数据库

大鼠基因ID

大鼠蛋白质序列数据库

细胞定位

组织表达

储存（Storage）

实验方案>

引用文献(0)>

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hnRNP A2/B1 Polyclonal Antibody

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