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Stat5 (phospho-Tyr694) rabbit pAb

说明书

BYab-01477

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC
分子量(DA)
90kD
免疫原
Synthesized phosho peptide around human Stat5 (Tyr694)
特异性
This antibody detects endogenous levels of Human Mouse Stat5 (phospho-Tyr694)
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度
1 mg/ml
背景(Background)
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provi
功能
disease:Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.,function:Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.,online information:STAT5 entry,online information:STAT5B mutation db,PTM:Tyrosine phosphorylated.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus in response to phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By simil
基因名称(Gene Name)
STAT5B
蛋白名称
Stat5 (Tyr694)
简称
Stat5
其他名称
Signal transducer and activator of transcription 5B
Fields
>>ErbB signaling pathway;>>Chemokine signaling pathway;>>Necroptosis;>>JAK-STAT signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>Prolactin signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Growth hormone synthesis, secretion and action;>>Hepatitis B;>>Measles;>>Human T-cell leukemia virus 1 infection;>>Pathways in cancer;>>Viral carcinogenesis;>>Chemical carcinogenesis - receptor activation;>>Chronic myeloid leukemia;>>Acute myeloid leukemia;>>Non-small cell lung cancer
人基因ID
6777
人蛋白质序列数据库
P51692
小鼠基因ID
20851
小鼠蛋白质序列数据库
P42232
大鼠基因ID
25126
大鼠蛋白质序列数据库
P52632
细胞定位
Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation. .
组织表达
Brain,Epithelium,Lymph,Placenta,
储存(Storage)
-20°C/1 year

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Stat5 (phospho-Tyr694) rabbit pAb

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