免疫原
Purified recombinant human RPA32/RPA2 protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of RPA32/RPA2 and does not cross-react with related proteins.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
wb dilution 1:2000 icc dilution 1:200
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
背景（Background）
function:Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.,PTM:Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis). Phosphorylated by ATR upon DNA damage, which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC/DNA-PK in the presence of Ku and DNA, and by CDC2.,subcellular location:Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage.,subunit:Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN.,
功能
function:Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.,PTM:Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis). Phosphorylated by ATR upon DNA damage, which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC/DNA-PK in the presence of Ku and DNA, and by CDC2.,subcellular location:Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage.,subunit:Heterotrimer of 70, 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN.,
其他名称
60S acidic ribosomal protein P1;AA409079;AI325195;AU020965;HSSB;ik:tdsubc_2g1;M(2)21C; MGC137236;OTTHUMP00000004008;p32;p34;RCJMB04_6d17 replication protein A2, 32kDa;REPA 2; REPA1;REPA2;Replication factor A protein 2;Replication protein A 32 kDa subunit; Replication protein A 32kDa subunit;Replication protein A 34 kDa subunit;Replication protein A;replication protein A1 (70kD);Replication Protein A2 (32kDa);Replication protein A2 32kD;Replication protein A2 32kDa;Replication protein A2;Replication protein A2, 32kDa;RF A;RF-A protein 2;Rf-A2;RFA;RFA2_HUMAN;RP A;RP-A p32;RP-A p34;RP21C;RPA 2; RPA 32;RPA;RPA2;RPA32;RPA34;RPA70;RpLP1;RpP2;xx:tdsubc_2g1;zgc:109822.
Fields
>>DNA replication;>>Nucleotide excision repair;>>Mismatch repair;>>Homologous recombination;>>Fanconi anemia pathway
细胞定位
Nucleus . Nucleus, PML body . Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner. .
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